Regeneration Of Lost Muscle Tissue Advancing Rapidly
start by implanting what’s called an extracellular matrix, a sort of
“cellular glue,” whose key components are growth factor proteins from
pig bladders. Those proteins trigger the body’s own stem cells to flock
to the area and initiate the process of tissue growth and wound repair”
By Dell Hill
Hat Tip - AoSHQ
medical advances one sees in an entire lifetime are simply incredible.
Today we’ll learn about yet another medical breakthrough that just
might astonish you. It’s the medical science of muscle regeneration and
the results of early testing are extremely promising.
Let’s get right the report from Wired.com.
few pig cells, a single surgery and a rigorous daily workout: They’re
the three ingredients that patients will need to re-grow fresh,
functional slabs of their own muscle, courtesy of Pentagon-backed
science that’s already being used to rebuild parts of people.
research team behind the project, based out of the University of
Pittsburgh, has made remarkably swift progress: Mere months after
starting their first-ever clinical trial, they’ve already operated on
four soldiers and are now training groups of surgeons from across the
country in perfecting the approach. If progress continues at this pace,
the trial will wrap in 24 months and the technique will become “a
standard of care for orthopedists and trauma surgeons,” according to Dr. Stephen Badylak, head of the initiative.
isn’t quite salamander territory, but it’s astonishingly close. The
Pittsburgh team’s research means that, within this decade, the thousands
of soldiers who’ve suffered major muscle loss during this decade’s wars
can overcome devastating impairment — a life sentence of chronic pain,
disability and no viable treatment short of amputation — and experience
at least a 25 percent improvement in physical function. For civilians,
the impact would incalculable. The kinds of trauma and health problems
that now cause amputation, from car accidents and fires to cancer or
diabetic peripheral vascular disease, would no longer cause irreparable
and colleagues at the University of Pittsburgh’s McGowan Institute for
Regenerative Medicine are only one of several groups leading far-out
research projects that are part of the Pentagon’s Armed Forces Institute of Regenerative Medicine
(AFIRM), a massive, $250 million undertaking meant to quickly usher
regenerative medicine into the mainstream. Already, military brass have fast-tracked clinical trials for “bone cement” to replace metal screws and plates and accelerated the sophistication of face and hand transplants — a handful of which have now been conducted in the United States.
The tantalizing prospect of regrowing tissue using Badylak’s technique first made headlines
in 2007, when he announced the successful regrowth of a small portion
of fingertip using a concoction based on cells derived from a pig’s
bladder. His approach with muscle tissue is similar: Surgeons start by
implanting what’s called an extracellular matrix, a sort of “cellular
glue,” whose key components are growth factor proteins from pig
bladders. Those proteins trigger the body’s own stem cells to flock to
the area and initiate the process of tissue growth and wound repair —
which adult muscles normally wouldn’t do. Combined with an intensive
rehab program to essentially “exercise” the nascent muscle, the body is
able to restore not only basic muscle tissue, but the tendons and nerves
that are necessary for function.”
Read this fascinating report in it entirety by clicking right here.